Effect of rat developmental stage at initiation on the expression of biochemical markers during liver tumor promotion
F Decloitre, C Lafarge-Frayssinet, M Barroso… - Tumor Biology, 1990 - karger.com
The phenotypic response of rat liver to a carcinogenic protocol involving initiation/selection
and promotion with and without phenobarbital (PB) feeding was studied in pubertal and
adult male rats. Considering the early presence of preneoplastic nodular areas, it appeared
that pubertal rats, initiated at 6–7 weeks, presented a higher susceptibility to the protocol
than adult rats initiated at 9–10 weeks. Altered liver phenotype was characterized by:(1) γ-
glutamyl-transpeptidase (GGT) and glutathione S-transferase (GST) activities;(2) the …
and promotion with and without phenobarbital (PB) feeding was studied in pubertal and
adult male rats. Considering the early presence of preneoplastic nodular areas, it appeared
that pubertal rats, initiated at 6–7 weeks, presented a higher susceptibility to the protocol
than adult rats initiated at 9–10 weeks. Altered liver phenotype was characterized by:(1) γ-
glutamyl-transpeptidase (GGT) and glutathione S-transferase (GST) activities;(2) the …
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